The Clarksville zinc refinery is located four kilometers southwest of Clarksville, Tennessee, beside the Cumberland River. Clarksville is located within 900 kilometers of the United States’ industrial heartland, including Chicago and Detroit.

A large portion of the U.S. zinc market lies within one-day delivery distance from the Clarksville smelter by road and low transport costs provide Nyrstar with a geographic competitive advantage. The smelter has its own river port that allows efficient supply of raw materials.